NASGBI Project Grant

The successful applicant for the NASGBI Project Grant was:

Principal Applicant
Dr Martin Smith
Consultant & Honorary Professor in Neuroanaesthesia & Neurocritical Care, University College London

Defining novel biomarkers of dysautoregulation after subarachnoid haemorrhage using non-invasive optical techniques


Scientific Abstract
Cerebral autoregulation (CA) describes the normal ability of cerebral vasculature to maintain cerebral blood flow despite changing perfusion pressure. It is frequently impaired after acute brain injury and this has been linked with poor outcome. Conventional methods of measuring CA are intermittent or invasive and the prospect of monitoring CA continuously and noninvasively at the bedside has obvious advantages. Near infrared spectroscopy (NIRS) provides a non-invasive, continuous measure of cerebral haemodynamics and metabolism and we hypothesise that novel analysis of NIRS signals will allow the identification of biomarkers of CA embedded within these signals. The aim of this research is to derive a number of potential biomarkers of CA using a wide range of advanced time- and frequency-domain data analysis techniques applied to previously collected NIRS data in patients with subarachnoid haemorrhage. This will allow us to identify key subsets of data that can be used as biomarkers of CA to guide clinical management and potentially extend treatment windows. We will use the output from this work to deliver clinically relevant information at the bedside and to design subsequent clinical outcome studies.
 Final Report from Dr M Smith (463 KB)